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[PubMed Citation] Pregnant animal studies Reproductive and developmental toxicity studies performed in rats at oral doses up to 6.7 times the recommended human intravenous dose and in rabbits at doses up to 3.3 times the recommended human intravenous dose revealed no evidence of impaired fertility or embryofetal toxicity

doi: 10.1056/nejmoa1308573 9 GramatzkiDRothPRushingEJWellerJAndratschkeNHoferSet al

Moreover, ROS directly stimulates the release of pro-inflammatory cytokines and activates the nuclear factor B (NF-B) pathway to cause inflammation ( In the three-hit hypothesis of X-ALD, oxidative stress is described as the first hit to cause axonal injury of AMN, or subsequently induce inflammatory demyelination and cell death of CALD, triggered by stochastic factors such as lipid peroxides, environmental factors, and genetics ( in vivo / in vitro studies have demonstrated that drugs targeting redox imbalance and inflammation effectively improve symptoms and prevent disease progression ( This study introduces the relationship between the X-ALD and oxidative stress and inflammation

Harding, G., Coyne, K