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Such vascular responses are particularly relevant in experimental models of ischemia, where enhanced circulation contributes to tissue preservation and recovery.(22) In addition to its effects on vascular growth, it has been associated with regulation of vascular tone through interactions with nitric oxidedependent signaling mechanisms

Angioni D, Middleton L, Bateman R et al (2025) Challenges and opportunities for novel combination therapies in Alzheimers disease: a report from the EU/US CTAD Task Force