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10.1038/nature11986 40

Although there is some evidence that carbidopa can bind to and form insoluble complexes with vitamin B-6 in test tubes (Daidone, PLoS One 2012), and an animal study has shown that repeated administration of extremely high doses of carbidopa can lower levels of vitamin B-6 in rats (Airoldi, Metabolism 1978), no strong evidence has confirmed this interaction in humans