napqi and glutathione A quantum chemical study of the reactivity of acetaminophen (paracetamol) toxic metabolite N-acetyl-p-benzoquinone imine with deoxyguanosine 5️⃣ Antidote: NAC (N-acetylcysteine) NAC

5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose. A crossomics analysis of acetaminopheninduced hepatotoxicity in rat liver Sumida 2015 Rapid Communications in Mass Spectrometry Wiley Online Library The molecular mechanisms of acetaminophen induced hepatotoxicity and its potential therapeutic targets PMC Problem 2 n acetyl para benzoquinone napqi is an oxidized

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