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Another glutaminase inhibitor, JHU-083, extensively inhibits Gln-metabolizing enzymes and increases the concentrations of Gln and glucose in the TME by inhibiting glycolysis, relieving the hypoxic state

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Its prevalence has risen dramatically since 1980, when it was a perplexing and sporadically-observed disease as first reported by Ludwig and colleagues (1), to a current estimated 25% global prevalence.(2) NAFLD represents the leading cause of chronic liver disease and is the second leading indication for liver transplantation in the United States.(3) Its rise parallels the obesity epidemic and is attributed to the concomitant rise in the prevalence of type 2 diabetes and metabolic syndrome