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Hence, in the design of nanocarrier-based drug delivery systems, the size of the nanocarrier plays a critical role in its ability to reach metastatic sites

[5] Energetics and reversibility Of the 61.9 kJ/mol (14.8 kcal/mol) released from the hydrolysis of the phosphoryl group of PEP, nearly half is conserved in the formation of the phosphoanhydride bond between ADP and P i , whose G is 30.5 kJ/mol (7.3 kcal/mol)