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With a molecular weight of just 403.93 Da well below the 500 Da cutoff typically associated with significant skin penetration GHK-Cu is small enough to penetrate the stratum corneum (outer skin layer) in concentrations sufficient to activate regenerative processes

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Experimental Cell Research 393 (2), 112109

IV saline hydration reaches dehydrated tissues far more quickly than drinking water alone especially after illness, travel, heat exposure, or alcohol consumption