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Lif Sci 189:4451 Acknowledgements This research was supported by Coordination of Improvement of Higher Level Personnel (CAPES) and Federal University of Ouro Preto (UFOP), Brazil

Maintain hormonal balance with Testosterone Cypionate Injections in grapeseed oil, a compounded hormone therapy used in testosterone replacement protocols

These findings suggest that the absence of endogenous itaconate removes an important regulatory brake on TGF- signaling and extracellular matrix production in IPF

These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism