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Contributions of glutamate and GABA systems to the neurobiology and treatment of schizophrenia

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In numerous embodiments, amphipathic lipids are included in lipid particles of the invention

Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025