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To act as a dipeptidyl peptidase, DAP BII must be able to fix the N-terminus in position

Senescent cells are known for their pro-inflammatory secretory phenotype, termed the Senescence-Associated Secretory Phenotype (SASP), which FOXO4-DRI effectively reduces, improving tissue function

It holds the promise to treat difficult and poor prognostic diseases such as cancers, complex infections, autoimmune diseases, and other clinical problems (Shen et al., 2018

In addition, the minipig model uses a higher level of shielding (55%) that would not necessarily be as applicable to a mass casualty situation (Measey et al., 2018