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One in vivo comparison of GHK versus GHK-Cu in rat experimental wounds found that GHK alone had no effect, and only the copper-bound GHK-Cu form produced a statistically significant increase in collagen accumulation evidence that the copper ion itself, not the peptide backbone alone, may be responsible for much of the collagen-stimulating activity

The dose-response curve in clinical trials was remarkably linear

VEGF), which further promote the formation of new blood vessels that invade neighboring matrix (Jun et al., 2007)

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