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Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility No evidence of carcinogenic potential was obtained in an 88-week carcinogenicity study of donepezil conducted in mice at oral doses up to 180 mg/kg/day (approximately 40 times the maximum recommended human dose [MRHD] of 23 mg/day on a mg/m2 basis), or in a 104-week carcinogenicity study in rats at oral doses up to 30 mg/kg/day (approximately 13 times the MRHD on a mg/m2 basis)

In regards to intestine peptide, bacteriostatic water should be the preferred method for reconstitution due to its ability to provide an environment conducive to preserving the longevity and stability of the peptide molecules over time

10.1016/j.neuint.2017.03.014 Neurochem