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However, even mild steroids can carry consequencesespecially at higher doses or when used without proper monitoring

indicum extract exhibited decreased levels of TNF-, IL-1, IL-6, and NF-B p65 protein

The low permeability of paracellular pathways is mainly determined by tight junctions (TJs), which mainly consist of densely distributed transmembrane protein claudin (especially claudin-5), occluding, tricellulins, junctional adhesion molecules, and intracellular support proteins such as zona occludens (ZO) (Haseloff et al., 2015

Over representation analysis was carried out using the MicrobiomeProfiler v.1.10.0 R package to identify the metabolic pathways using KEGG (Kyoto Encyclopedia of Genes and Genomes) database involved in each significant module generated by the WGCNA analysis