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The main reasons for vitamin B12 deficiency are: Dietary deficiency, mainly in vegans and vegetarians Pernicious anemia , an autoimmune condition affecting intrinsic factor production Malabsorption due to gastrointestinal disorders or surgery Folate Deficiency-Related Megaloblastic Anemia Folate is also vital for DNA and red blood cell production

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The difference between the two is the rate of formation and the density of the layer

doi: 10.1089/ast.2016.1600, 100 SchindelinJ.Arganda-CarrerasI.FriseE.KaynigV.LongairM.PietzschT.et al