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Summary Keywords organoid, 3D cultures, spheroids, mitochondrial diseases, neurodevelopmental disorders, high-throughput screening, drug repurposing Citation Coronel R, Garca-Moreno E, Siendones E, Barrero MJ, Martnez-Delgado B, Santos-Ocaa C, Liste I and Cascajo-Almenara MV (2024) Brain organoid as a model to study the role of mitochondria in neurodevelopmental disorders: achievements and weaknesses

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline Solubility: 2.5 mg/mL (11.72 mM)

6.1 Dysregulation of the Angiopoietin-Tie2 axis and vascular barrier disintegration The maintenance of vascular endothelial permeability is highly dependent on the binding of Angiopoietin-1 (Ang-1) to the Tie2 receptor on the surface of endothelial cells, a homeostasis that is a core mechanism guaranteeing vascular maturation and stability (85, 86)