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Liu MC, Bleecker ER, Lichtenstein LM, Kagey-Sobotka A, Niv Y, Mclemore TL, Permutt S, Proud D, & Hubbard WC (1990) Evidence for elevated levels of histamine, prostaglandin D 2 , and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma

They simultaneously enhance regulatory T-cell (Treg) activity and facilitate macrophage reprogramming to an anti-inflammatory phenotype (IL-10), thereby reestablishing Th17/Treg ratios that are altered in autoimmune POF (He et al