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Medgranate, Medinutrex, Catania, Italy) used in this study was derived from Wonderful variety pomegranate by-products (exhausted peels, membranes, and arils) via industrial drying to 5% moisture, hydroalcoholic extraction (ethanol/water 60:40 v/v, 1:10 w/v, 24 h stirring), alcohol recovery, and spray-drying (30% yield), and has been previously characterized and validated for its polyphenolic profile and bioactivity in in vitro models of prostate cell lines demonstrating antioxidant and anti-proliferative effects (Consoli et al., 2023)