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performed transcriptomic profiling which demonstrated that Pterostilbene influenced the expression of genes related to sulfur metabolism by downregulating six genes (ECM17, MET3, MET14, MET16, MET10, and MET6) that encode enzyme regulating methionine biosynthesis (23)

Increased tryptophan metabolism can lead to a shift toward the KYN pathway (76)

[32] ERCP and specialized techniques may also be needed to help distinguish between a benign PSC stricture and a bile-duct cancer (cholangiocarcinoma)