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Abstract Steroidal 5-reductase is a system of NADPH dependent enzyme that catalyzes the irreversible conversion of 43-ketosteroid precursor (testosterone) to its corresponding 5-reduced metabolite (dihydrotestosterone)

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(Barbagallo et al., 2022) demonstrated that NAD + supplementation activates Sirtuin 2 (SIRT2), enhancing the reciprocal inhibition of forkhead box O1 (FOXO1) and PPAR- to inhibit adipocyte differentiation and induce fat loss