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10.1113/EP091707 161 KovacevicA.MavrosY.HeiszJ

Unlike other organelles such as mitochondria, where an abundance of reduced glutathione (GSH) preserves a reductive environment, the ER requires an oxidizing milieu to facilitate the formation of disulfide bonds critical for protein structural integrity

Effect modification between genes and environment and Parkinsons disease risk

Patients addressing acute oxidative load recovery from illness, heavy travel, post-surgical support may run a higher-frequency loading protocol up front