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Nature 503 , 267271 (2013)

BioEssays 39:240

366,367 In earlier clinical studies, the suitability of the population for intensified treatment remains unclear, with inconsistent intensity and duration of CDK4/6 inhibitors and inadequate management of their toxic side effects

The pro-inflammatory cytokine TNF- can induce NF- with proinflammatory effects or can upregulate A20, the ubiquitin-modifying protein that inhibits NF- signaling (Wang et al., 2013)