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Intraperitoneal administration, used primarily in animal studies for convenience, results in faster absorption through the highly vascularized peritoneal membrane, shortening the dihexa half life to one to two hours and producing higher peak plasma concentrations

Science 336 , 474477 (2012)

Perez-Rivas LG, Theodoropoulou M, Ferrau F, Nusser C, Kawaguchi K, Stratakis CA, Faucz FR, Wildemberg LE, Assie G, Beschorner R, Dimopoulou C, Buchfelder M, Popovic V, Berr CM, Toth M, Ardisasmita AI, Honegger J, Bertherat J, Gadelha MR, Beuschlein F, Stalla G, Komada M, Korbonits M, Reincke M