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Apoptosis-Inducing Activity of Clofazimine in Macrophages

PMC 4079069

To validate the on-target engagement of iMQT_020, we used SLC1A5_var-knockdown cell lines overexpressing one of four constructs: control, wild-type SLC1A5_var (WT), a sodium-binding site mutant (SLC1A5_var D/A), or a trimer interaction mutant (SLC1A5_var FIL/AAA)