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More importantly, the downregulation of the EZH2 gene leads to a decrease in LAT1 ( SLC7A5 ) expression, and, in turn, the downregulation of LAT1 ( SLC7A5 ) or the depletion of essential amino acids can also induce a decrease in EZH2 expression (Dann et al., SLC7A5 ) indicates the potential of LAT1 ( SLC7A5 ) as a target for cancer therapy (Hafliger and Charles, 2019)

In particular, the improvement of intestinal wall integrity occurs due to the three main mechanisms: i) increased expression of TJ proteins, ii) decreased levels of pro-inflammatory molecules, and iii) increased intracellular antioxidant potential (Sandoval-Ramrez et al., 2021)

Acute and post-acute sequelae of SARS-CoV-2 infection: a review of risk factors and social determinants

10.1074/jbc.M100489200 [DOI] [PubMed] [Google Scholar] Shimizu S, Juan ECM, Sato Y, Miyashita YI, Hoque MM, Suzuki K, Sagara T, Tsunoda M, Sekiguchi T, Dock-Bregeon A-C, et al