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This implies that LRRK2 kinase activity regulates GCase in a cell-type specific manner, as neurons derived from individuals with LRRK2 PD show reduced GCase activity which can be rescued by inhibition of LRRK2 kinase activity via MLi-2 211

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[11] Each domain individually is very similar to the analogous domains in glutathione reductase and lipoamide dehydrogenase, but the relative orientation of these domains in ThxR is rotated by 66 degrees

Mechanochemical disruption suppresses metastatic phenotype and pushes prostate cancer cells toward apoptosis