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10.1177/2047487319880043 152 Nogueira-MachadoJ

Some anecdotal and small observational reports support vasodilator therapies for Raynauds

Data availability The datasets used and/or analyzed during the current experiment are available from the corresponding author on reasonable request

Melatonin at doses of 1 mg to 10 mg has been shown to worsen glucose tolerance and insulin sensitivity compared to placebo in men as well as in pre- and postmenopausal women after a single dose and persisting after up to three months.44 Some studies have noted a genetic component to this tendency as well as the possibility that the timing of supplementation and meals may be helpful in attenuating this effect.45 ALA Supplements Since food-sourced ALA is unlikely to have a significant impact on endogenous levels, the question of supplementation is of strong interest