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In bleomycin-induced fibrotic mice and TGF-1-challenged A549 cells, Nintedanib restores E-cadherin while reducing vimentin and -SMA, chiefly by suppressing the PI3K/Akt/mTOR axis to halt TGF-1-driven migration, trans-differentiation and ECM deposition ( By contrast, Nerandomilast, a novel selective phosphodiesterase-4 (PDE4) inhibitor, has recently attracted considerable attention in pulmonary-fibrosis research

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