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A recent study reported that ferroptosis was induced in mice with UC, as evidenced by ferrous iron accumulation, elevated ROS production, the depletion of superoxide dismutase (SOD) and GSH, and the reduced expression of GPX-4 and ferritin heavy chain (FTH), accompanied by the increased expression of transferrin (TF)

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J Inherit.Metab Dis 2008;31 Suppl 2:S453-S456

Lack of Opp periplasmic binding protein OppA or permease OppC results in decrease of GSH-dependent reduction of Grx1-roGFP2 in GSH-deficient cells Thus far, our data suggested to us that Gsi is the only permease capable of importing oxidized glutathione into the cytoplasm and that Opp is a highly efficient permease for reduced glutathione