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doi: 10.1523/ENEURO.0097-22.2023, 151 OlthofB

Figure 6.1 A split myelin sheath surrounding an axon in layer 4 of area 46 in prefrontal cortex of a 35 year old monkey

& Trevithick, J

Degradation, mainly includes fragmentation, hydrolysis, and cleavage, refers to the destruction of protein structure in the production of RTPs under the action of enzymes or non-enzymes, resulting in the heterogeneity of glycosylation, charge, etc., which are crucial to the stability, half-life, immunogenicity, and biological function of the drug (Nguyen and Zimmer 2023