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Messali A, Sanderson JC, Blumenfeld AM, et al

Science 342 (6162), 10941098

Metabolic pathways requiring thiamin pyrophosphate (TPP) The figure shows the various enzymes requiring TPP as a cofactor: In the cytosol, TPP is required for transketolase, which converts ribose 5-phosphate in the pentose phosphate cycle to glyceraldehyde 3-phosphate, which is converted to pyruvate in glycolysis