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The interaction and mutual promotion of these three factors are thought to be responsible for the concentrated epidemic of cretinism in Central Africa ( Figure 2 It is thought-provoking that Se supplementation in iodine-deficient populations in this region can have serious and incalculable consequences ( This enlightens us that Se supplementation should not be done indiscriminately in patients with congenital hypothyroidism (CH)

Although RE demonstrated strong absorption following oral administration in humans, its bioavailability remained limited [92]

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