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Unlike many neurotrophic factors that are difficult to administer, Dihexa possesses three essential properties that make it highly valuable for neurological research: it is orally active, metabolically stable, and capable of crossing the bloodbrain barrier

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39 reported that daf-7 mutants and wild-type worms treated with daf-7 RNAi exhibited an increased lifespan, Fletcher and Kim 12 more recently demonstrated that DAF-7 promotes lifespan extension in response to dietary restriction and that age-dependent reduction in daf-7 expression impairs the sensitivity of aged worms to the effects of dietary restriction on lifespan