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subtilis abundance is reduced in an age-dependent manner, supporting GBA1 function by microbial supplementation could limit -synuclein pathology

Limitations of Available Evidence Research varies based on study design, dosing, and delivery method

At the organism level, NAD+ supplementation significantly prolongs the life span of Caenorhabditis elegans and Drosophila melanogaster affected by Werner Syndrome (WS) and delays animal aging and stem cell dysfunction

van Ophoven A, Pokupic S, Heinecke A et al: A prospective, randomized, placebo controlled, double-blind study of amitriptyline for the treatment of interstitial cystitis