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By developing consensus guidelines, multidisciplinary collaboration can be promoted, evaluation standards for treatment efficacy and side effects can be unified, and treatment strategies can be optimized, thereby improving overall safety and effectiveness

10.1093/eurheartj/ehz455 75 MaiolinoG.RossittoG.CaielliP.BisogniV.RossiG

Aim The objective of this review was to evaluate the mechanisms of action of melatonin on oxidative stress, inflammation and intestinal dysbiosis caused by MS, as well as its interaction with different hormones and factors that can influence the pathophysiology of the disease

611,612 For example, in a study examining 365 elderly participants, a higher brain concentration of MK-4 was associated with a 17-20% lower risk of MCI