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It has been demonstrated that fatty acid derived -OHB specifically activates HCAR2 receptors within physiologically relevant -OHB concentrations (K i = 0.7 mM) (Taggart et al., 2005), typically observed in serum during short-term fasting

Although Fancc may be primarily expressed by glia at later AD stages, our IHC experiments indicate that Fancc expression is prominent in neurons at these earlier pre-plaque stages