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Anhidrosis (lack of sweat) may occur and produce heat intolerance or impair temperature regulation in persons living in a hot environment

3 The mechanisms of TCM in preventing and treating elderly diabetes The prevalence of diabetes among the elderly is high, and overall blood glucose control is suboptimal

On the other hand, the inhibition of Nrf2 signaling might be employed to enhance the sensitization of chemoresistant tumors to cytotoxic agents, and in this context, it has recently been reported that brusatol, a compound found in a plant extract, acts as inhibitor of this pathway and may exhibit therapeutic utility [111]

CNS : stimulation of central presynaptic 2 receptors causes a decrease in release of norepinephrine and dopamine resulting in