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Description

These treatments can be effective, particularly in mild cases or when the condition is detected early

To investigate the mechanism of GSH dependent transport mediated by MRP1, we localized on the 3D structure of the transporter 40 two putative GSH binding sites deduced from the numerous mutagenesis studies done in the past two decades on MRP1 compiled in the database 50 , one located in the cytoplasmic face and the other located in the membrane (Fig