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Role of Hyperphosphatemia In CKD stages G4-G5 hyperphosphatemia becomes an increasingly frequent feature (21), due to phosphate retention caused by the progressive loss of functioning nephrons and the increasing difficulty in augmenting glomerular phosphate ultrafiltration and to further reduce its tubular reabsorption when it is already maximally inhibited by high serum FGF23 and PTH levels

However, despite these complications, several patients are older than the mean expected life expectancy for patients with vEDS 25 and 11 patients have not had any GI or vascular complications, although 4 of these 11 are pediatric patients

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