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Critical Appraisal of Clinical Evidence While numerous studies have investigated the effects of selenium supplementation in critically ill and trauma patients, significant methodological variations exist, contributing to inconsistent clinical outcomes

Importantly, ferroptosis has been implicated in osteoporosis associated with aging, glucocorticoid exposure, and diabetes [12,13,14], conditions that also show elevated circulating LCN2 [4, 15,16,17]

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