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For instance, H 2 O 2 is able to directly induce DNA double stand breaks (DSB) within the oocyte genome 97 and these lesions have been associated with chromosome misalignment and spindle defects at MII 98

In the NEJM Phase 2 trial, participants assigned to an initial dose of 4 mg experienced significantly more adverse events than those who started at 2 mg, even when both groups ultimately reached the same target dose