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doi: 10.1007/s00284-020-02243-5 184 SomashekaraiahRShruthiBDeepthiBVSreenivasaMY

This herb is derived from the plant Senna alexandrina and found in many common over-the-counter laxatives (24)

The anti-atrophy mechanism of PCHP involved maintaining protein metabolism homeostasis in the gastrocnemius muscle through the IL-6/signal transducer and activator of transcription 3 (STAT3)/cathepsin L (CTSL) and Diacylglycerol kinase (DGK)/the forkhead box O-class (FoxO)/Atrogin1 signaling axis, mediating the ubiquitin-proteasome and autophagy-lysosome systems, and downregulating the accumulation of ceramide via sphingomyelin phosphodiesterase 2 ( 5.1.7 Anti-obesity PCHP could markedly reverse insulin resistance as indicated by a reduction in obesity markers, enhanced leptin and fasting blood glucose levels, and improvements in serum lipid profiles