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This ratio of GSH:GSSG is maintained by the action of the enzyme GSSG reductase (also known as glutathione reductase) which requires NADPH+ as the reducing cofactor

10.1146/annurev-med-041316-085215 31 IbrahimI

Gudmundsdottir AB, Omarsdottir S, Brynjolfsdottir A, Paulsen BS, Olafsdottir ES, Freysdottir J (2015) Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17+ RORt+/IL-10+ FoxP3+ ratio in CD4+ T cells