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A more recent study also used ultrasensitive single-molecule arrays to detect brain injury biomarkers in urine from patients with IS and intracerebral hemorrhage, and found that higher urine GFAP (and to a lesser extent urine NfL and t-tau) levels in patients correlated with injury burden and in-hospital death or death by 3 months (77)

Kade IJ, Balogun BD, Rocha JB

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In summary, advancing the field of human neuroprotection demands a multidimensional recalibration, spanning conceptual clarity, more representative preclinical models, validated biomarkers, and refined clinical endpoints