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Older adults (there is reduced stomach acid production with age, and acid in the stomach is necessary to absorb vitamin B12)

The absolute risk increase for diabetic retinopathy complications was larger among patients with a history of diabetic retinopathy at baseline (semaglutide injection 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide injection 0.7%, placebo 0.4%)

This difference could be particularly relevant in formulations designed to address environmental damage or photo-aging

This exceptional safety profile was consistent across multiple dose levels, administration routes, and treatment durations