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95,116 Beyond mitochondria and the NOX family, a variety of enzymes including xanthine oxidase (XO), NOS, lipoxygenase and cytochromes P450 (CYP) can all produce ROS using NAD(P)H as electron donor

Although increasing hydrophobicity may seem an attractive option at the in vitro stage, poor solution behavior would pose a considerable challenge during formulation and testing in vivo