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Collectively, these biochemical properties position forskolin as a valuable molecule for developing treatments aimed at reducing IOP, protecting against oxidative and inflammatory damage, and preserving neuronal health in various eye diseases (Figure 4)

This is not proof of clinical harm at therapeutic doses, but it provides a plausible mechanistic basis for concern

Samples were collected at 0 h (G1/S phase), 5 h (S phase), and 10 h (G2 phase) after release from the block

In the majority of cases, the final outcome of the sulfation reaction is a molecule with increased hydrophilic properties and inactivation of biologically active compounds (Gamage et al., 2006)