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immune cells are among the most GSH-dependent in the body Redox signalling the GSH/GSSG (reduced/oxidised) ratio is a master regulator of cellular redox state, modulating transcription factors including NF-B and Nrf2 Protein maintenance glutathionylation protects cysteine residues in proteins from irreversible oxidation, preserving enzyme function Glutathione levels decline with age, chronic illness, toxin exposure, and oxidative stress contributing to accelerated cellular aging, impaired detoxification, and systemic inflammation

Ankersen et al., PMID 9733495) anchor the adverse-event picture