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These findings indicate that iron has a greater inhibitory effect on osteoblast precursors than on mature osteoblasts during osteogenic induction, which is similar to the regulation of osteoclasts by TFR1

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Tommy et al., 2021), (b) some of their pharmacogenomics target genes (e.g., Sm11/leucovorin downregulates IFNG, the gene coding for the inflammatory cytokine Interferon gamma ) , and (c) their abovementioned anti-correlative genes hubs are mainly related to immune and inflammation processes