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Acknowledgements This study was supported by grant from National Natural Science Foundation of (82100806,82270802,82170775,82370765), The Open Project of Hubei Key Laboratory 2023KFZZ009 and The Fundamental Research Funds for the Central Universities 2042023kf0022

The use of growth factors, both in animal models and in clinical trials, has shown promising effects in protecting dopaminergic neurons and astrocytes in damaged regions by the activation of different signaling pathways important in neuronal survival and regeneration

Whenever RBCs are exposed to higher H 2 O 2 levels, CAT becomes essential for its rapid removal since this enzyme has a high turnover rate, unlike GPx and Prx2 that become less efficient (or even inactive), due to their slow GSH reductase and Trx recycling systems, respectively [59, 60, 73]