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DHS (trans 4,4-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2)

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At the same time, high H 2 O 2 levels in the ER are a risk factor with potential for beta cell dysfunction, as documented by the fact that an increase of the low expression level of the antioxidative enzyme Prdx4 in rodent beta cells through overexpression goes along with enhanced glucose-induced insulin secretion due to increased proinsulin mRNA transcription and insulin content (Mehmeti et al

10.1016/j.carbpol.2024.122894 5 ChenZ.MoQ.MoD.PeiX.LiangA.CaiJ.et al (2025b)